> Our patented microcurrent signal causes tissues to release SDF-1 the universal stem cell homing signal (investigational use only). > Working with our partner in Florida, Bioheart, Inc. (founded by Leonhardt Ventures 1999), we are able to harvest stem cells from fat tissue at the clinic with a kit OR back in their GLP certified lab –http://www.bioheartinc.com/assets/press/FDAregistration.pdf– in Sunrise, Florida with expansion of quantity by cell culturing (investigational use only – training courses are available) – EyeCell is developing a series of clinical trials for utllizing of stem cells and endothelial progenitor cells combined with microcurrent stimulation for the treatment eye diseases such as wet and dry macular degeneration and seeks co-investigators and researchers to join us.
Stem cell trial sets sight on blindness
Transcorneal electrical stimulation rescues axotomized retinal … – NCBI
www.ncbi.nlm.nih.gov/pubmed/15914636
by T Morimoto – 2005 – Cited by 108– Related articles
Transcornealelectrical stimulationrescues axotomized retinal ganglion cells by activating endogenous retinalIGF–1system. Morimoto T(1), Miyoshi T, Matsuda…
Electrical stimulation modulates IGF binding protein transcript levels in …
www.ncbi.nlm.nih.gov/pubmed/15584093
by S Bayol – 2005 – Cited by 20– Related articles
Cell Biochem Funct. 2005 Sep-Oct;23(5):361-5.Electrical stimulationmodulatesIGFbinding protein transcript levels in C2C12 myotubes. Bayol S(1), Brownson…
Effect of electrical stimulation on IGF-1 transcription by L … – Springer
link.springer.com/article/10.1007%2Fs10384-008-0533-y
by T Sato – 2008 – Cited by 29– Related articles
Jul 27, 2008 –To investigate the effect ofelectrical stimulation(ES) on the induction of insulin-like growth factor 1 (IGF–1) in cultured retinal Müller cells.
IGF-1 Controlled Release by Bioelectric Stimulation Provisional Patent …
mysocialgoodnews.com/igf–1-controlled-release-bioelectric–stimulation-provisional-p…
Apr 2, 2016 –socialentrepreneurship, impact investing, philanthropy … The startups viaLeonhardtVentures have filed a provisional patent application with … Dr. Genovese has been conductingelectrical stimulationbased regeneration …. Provisional Patent Application |My SocialGood News on HowardLeonhardtto.
SDF-1 STEM CELL HOMING PROPERTIES
Low current electrical stimulation upregulates cytokine expression in …
www.ncbi.nlm.nih.gov/…/22006493
National Center for Biotechnology Information
by L Salcedo – 2012 – Cited by 4– Related articles
Oct 18, 2011 –Low currentelectrical stimulationupregulates cytokine expression in the … After 1-h stimulation and euthanasia 24 h after,SDF–1and MCP-3…
SDF-1 Effect on Hematopoietic Progenitor and Stem Cell Mobilization …
https://www.rndsystems.com/…/sdf–1-effect-hematopoietic-progenitor-a…
R&D Systems
SDF–1plays a key role in providing these directional cues, orchestrating CD34+cellmigration andhomingfrom the fetal liver into the BM.4,6-8 BothSDF–19and…
How do stem cells find their way home? | Blood Journal
www.bloodjournal.org/content/106/6/1901
by T Lapidot – 2005 – Cited by 894– Related articles
Homingis thought to be a coordinated, multistep process, which involves signaling by stromal-derived factor 1 (SDF–1) andstem cellfactor (SCF), activation of…
SDF-1 EYE REGENERATION PROPERTIES
Stromal Cell-Derived Factor-1 Is Essential for Photoreceptor …
National Center for Biotechnology Information
by H Otsuka – 2010 – Cited by 23– Related articles
SDF–1blockade with a neutralizing antibody increased photoreceptor cell loss and … cells to neovascularization andregenerationsites in heart, liver,,andeye.,… In someeyes, immediately after RD induction, 1 μg anti-SDF-1α antibody..
CXCL12/SDF-1 facilitates optic nerve regeneration. – NCBI
National Center for Biotechnology Information
by A Heskamp – 2013 – Cited by 16– Related articles
Neurobiol Dis. 2013 Jul;55:76-86. doi: 10.1016/j.nbd.2013.04.001. Epub 2013 Apr 8. CXCL12/SDF–1facilitates optic nerveregeneration. Heskamp A(1).
IGF-1
Induction of retinal regeneration in vivo by growth factors. – NCBI
www.ncbi.nlm.nih.gov/pubmed/1936569National Center for Biotechnology Information
by CM Park – 1991 – Cited by 115– Related articles
Induction of retinalregenerationin vivo bygrowth factors. … Polymer implants containing bFGF were inserted intoeyesof chicken embryos immediately … factor-beta, transforminggrowth factor-beta 1,insulin, orinsulin–like growthfactors I or II.
Effect of insulin-like growth factor-1 on corneal surface ultrastructure …
www.ncbi.nlm.nih.gov/…/24211688National Center for Biotechnology Information
by C Wang – 2014 – Cited by 4– Related articles
Nov 7, 2013 –Effect ofinsulin–like growthfactor-1 on corneal surface ultrastructure and nerve regeneration of rabbiteyesafter laser in situ keratomileusis. … IGF-1 can effectively accelerate the earlyrepairof corneal surface ultrastructure…
Norrin mediates angiogenic properties via the induction of insulin-like …
www.ncbi.nlm.nih.gov/…/26706283
National Center for Biotechnology Information
by LF Zeilbeck – 2015 – Related articles
Dec 17, 2015 –(2)Laboratory for Experimental Immunology of theEye, Department of Ophthalmology, … Moreover, Norrin induces vascularrepairfollowing an … Sinceinsulin–like growthfactor (IGF)-1 is a very potent angiogenic molecule,…
HGF
Hepatocyte Growth Factor Promotes Long‐Term Survival …
https://www.deepdyve.com/…/hepatocyte–growth–factor-promotes-long-t…
Jun 4, 2014 –Read “Hepatocyte Growth FactorPromotes Long‐Term Survival and … AxonalRegenerationof Retinal Ganglion Cells after Optic Nerve …eyewas performed either immediately after injury or delayed until 7 days post-injury.
FOLLISTATIN
Tissue absence initiates regeneration through Follistatin …
elifesciences.org/content/2/e00247
eLife
by MA Gaviño – 2013 – Cited by 16– Related articles
Sep 10, 2013 –Tissue absence initiatesregenerationthroughFollistatin-mediated inhibition of … (D) fst(RNAi) animals lackedeyeprogenitors following head…
EYE REGENERATION GENERAL
An Eye on Regeneration – NCBI – National Institutes of Health
National Center for Biotechnology Information
by MK Call – 2005 – Cited by 11– Related articles
Lensregenerationin newts is a remarkable process, whereby a lost tissue is replaced by transdifferentiation of adult tissues that only a few organisms possess.
Regenerating Lost Vision in Glaucoma | Glaucoma …
www.glaucoma.org/…/regenerating-lost-…
Glaucoma Research Foundation
Feb 10, 2016 –When we catch glaucoma early enough, we are fortunate in much of the developed world to be able to lowereyepressure with medicine or…
How fish can regenerate eye injuries at the cellular level — ScienceDaily
https://www.sciencedaily.com/releases/2016/05/160506100241.htm
Science Daily
May 6, 2016 –Scientists have examined the key function in the process ofregenerationin theeyesof fish. Surprisingly, a single genetic factor triggers two…
Drug ‘cocktail’ could restore vision in optic nerve injury – Vector
vector.childrenshospital.org/…/drug-cocktail-could-restore-vision-in-optic-nerve-injur…
Jan 14, 2016 –Gene therapy achieved extensive optic nerveregeneration, … keygrowth factors(osteopontin,insulin–like growthfactor 1 and ciliary neurotrophic factor. … But the axons weren’t able to carry signals all the way from theeyeto…
VEGF and eNOS
VEGF-B can regenerate damaged peripheral nerves without …
www.news-medical.net/…/VEGF-B-can-regenerate-damaged-peripheral-…
Nov 18, 2014 –But ifVEGF-B was delivered to the corneas of these mice, nerveregenerationimproved. The new nerves restored normal sensation to theeye,…
Growth factor regenerates damaged nerves without …
https://news.uic.edu/growth-factor-regen…
University of Illinois at Chicago
Nov 17, 2014 –VEGF-A is a factor that Rosenblatt and several others have studied … But ifVEGF-B was delivered to the corneas of these mice, nerveregenerationimproved. The new nerves restored normal sensation to theeye, and proper…
Endogenous VEGF Is Required for Visual Function …
journals.plos.org/plosone/article?id=10.1371/journal.pone.0003554
by M Saint-Geniez – 2008 – Cited by 332– Related articles
Nov 3, 2008 –To examineVEGFexpression patterns in adulteye, we used mice …… of retinal ganglion cell development, survival, andregeneration.
ACTIVIN A+B
Neural Regeneration and Cell Replacement: a view from the eye – NCBI
www.ncbi.nlm.nih.gov/…/PMC26922…
National Center for Biotechnology Information
by D Lamba – 2008 – Cited by 119– Related articles
Jun 5, 2008 –Studies ofeye regenerationhave a long history, dating back to the …B. The retina first becomes recognizable at the optic vesicle stage of development. …. stimulateregeneration(Spence et al., 2007), whileactivinsignaling…
STEM CELLS
Stem cells in retinal regeneration: past, present and future
National Center for Biotechnology Information
by CM Ramsden – 2013 – Cited by 101– Related articles
Retinal disease candidates for stem cell-basedregeneration… Theeyeis easily accessible and there is a wealth of surgical expertise in dealing with the …. In the case of wet AMD, intravitreal injection ofanti–VEGFagents can stabilise the…
Stem cells regenerate human lens after cataract surgery, restoring …
https://www.sciencedaily.com/releases/2016/03/160309135653.htm
Science Daily
Mar 9, 2016 –In the case of the humaneye,lensepithelialstem cellsor LECs generate replacementlenscells throughout a person’s life, though production…
A blind woman has regained sight following a controversial stem cell …
www.sciencealert.com/a-blind-woman-has-regained-sight-thanks-to-a-controversial-st…
Feb 29, 2016 –The doctor who performed thestem celltreatment, ophthalmologist Jeffrey … a case study on Belton in the journal NeuralRegenerationResearch. …stem cellswere injected into her righteye’sretina and lefteye’soptic nerve?
MICRO PUMP
Implanted Ophthalmic Micropump – Enhanced Vision
https://www.enhancedvision.com/…vision…/implanted-ophthalmic-micro…
Anyone who gets frequenteyeinjections for wet AMD or diabetic macular edema would be quick to agree that if there was a treatment that made it possible to…
BioElectric and Microcurrent Stimulation
Microcurrent Stimulation | Ophthamologist – Eye Diseases …
www.healingtheeye.com/microcurrent.html
Many patients become interested inmicrocurrentafter reading my bookMicrocurrentStimulation: MiracleEyeCure and they expect to experience the same type…
Search Results
[PDF]
Electrical Stimulation to Enhance Axonal Regeneration after … – Utah
content.lib.utah.edu/utils/getfile/collection/ehsl-nam/id/1201/filename/image
Introduction: The inability of CNS axons toregenerateafter injury is attributable both to …Electrical stimulationof the optic nerve elevates cAMP levels … inhibitor isobutyl methylxanthine was injected into a subset of theseeyespost-stimulation.
Axonal regeneration induced by repetitive electrical stimulation of …
www.ncbi.nlm.nih.gov/…/19484445
National Center for Biotechnology Information
by Y Tagami – 2009 – Cited by 33– Related articles
May 31, 2009 –Axonalregenerationinduced by repetitiveelectrical stimulationof … from a corneal contact lens electrode, was used to stimulate theeye.
Therapeutic Electrical Stimulation helps to improve vision without …
https://www.restore-vision.com/new-therapy-restore-vision/
Impaired or poorvisioncan be improved or stabilized within few weeks by using non invasive therapeuticelectrical stimulation.
First-ever restoration of vision achieved in mice | News Center …
https://med.stanford.edu/news/…/first-ever-restoration-of-vision-achieved-in-mice.htm…
Jul 11, 2016 –In experiments in mice described in astudypublished online July 11 in Nature Neuroscience, the scientists coaxed optic-nerve cables, responsible for conveying visual information from the eye to thebrain, intoregeneratingafter they had been completely severed, and found that they could retrace their…
Endogenous bioelectric currents promote differentiation of the …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724684/
by L Cao – 2018
Aug 30, 2017 –An EF also promoted theexpressionof β‐crystallin, aquaporin‐0 (AQP0) and the Beaded Filament StructuralProtein2 (BFSP2) in lens epithelial cells (LECs), all of which are hallmarks of differentiation. In addition, applied EF activated the AKT and CDC2 and inhibition of AKT reduced the activation of…
A Bionic Lens Undergoing Clinical Trials Could Give You Superhuman Abilities In Two Years
Transcorneal Electrical Stimulation Rescues Axotomized Retinal …
iovs.arvojournals.org/article.aspx?articleid=2163762
by T Morimoto – 2005 – Cited by 132– Related articles
TranscornealElectrical StimulationRescues Axotomized Retinal Ganglion Cells by Activating Endogenous RetinalIGF-1System …. at 4°C. The supernatants were collected, and the protein concentration was determined by the Bradford protein assay withbovineserum albumin as a standard (Bio-Rad, Hercules, CA).
Eye regeneration technique lets blind mice see the light | Science …
www.sciencemag.org/news/2018/…/eye-regeneration-technique-lets-blind-mice-see-li…
Regenerating Eye Tissues to Preserve and Restore Vision – Cell Press
https://www.cell.com/cell-stem-cell/pdf/S1934-5909(18)30231-5.pdf
by JH Stern – 2018 – Cited by 2– Related articles
Jun 1, 2018 –studies for stem cell-based repair, covering keyeyetissues from front to back, from cornea to retina, and including
Microcurrent stimulation in the treatment of dry and wet macular …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689270/
by L Chaikin – 2015 – Cited by 6– Related articles
Dec 17, 2015 –There were 25eyeswithdry age-related macular degeneration(DAMD) and sixeyeswithwet age-related macular degeneration(WAMD).
Abstract·Introduction·Methods·Results
(PDF) Microcurrent stimulation in the treatment of dry and wet macular …
https://www.researchgate.net/…/288836543_Microcurrent_stimulation_in_the_treatment…
Jul 31, 2018 –There were 25eyeswithdry age-related macular degeneration(DAMD) and sixeyeswithwet age-related macular degeneration(WAMD).